Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | BCR | P11274 | 1/20 | 0.55 |
| ▸ | PLK1 | P53350 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782288 | 0.86 | AURKA (0.57) | AURKAABL1BCRPLK1HTT | |
| SCHEMBL4943590 | 0.85 | AURKA (0.58) | AURKAABL1BCRPLK1HTT | |
| SCHEMBL4950822 | 0.79 | AURKA (0.55) | AURKAABL1BCRPLK1HTT | |
| SCHEMBL2921258 | 0.75 | AURKA (1.00) | AURKAABL1BCRPLK1CCNA2 | |
| SCHEMBL2918890 | 0.74 | CCNA2 (0.70) | AURKAABL1BCRPLK1ALDH1A1 | |
| SCHEMBL2917872 | 0.74 | AURKA (0.75) | AURKAABL1BCRPLK1CCNA2 | |
| SCHEMBL2919637 | 0.73 | AURKA (0.71) | AURKAABL1BCRPLK1LMNA | |
| SCHEMBL806924 | 0.73 | BRD4 (0.58) | AURKAABL1BCRPLK1 | |
| SCHEMBL2923322 | 0.72 | AURKA (1.00) | AURKAABL1BCRPLK1ALDH1A1 | |
| SCHEMBL2922712 | 0.72 | CCNA2 (0.70) | AURKAABL1BCRPLK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008017465-A1 | BICYCLIC LACTAM DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-14 | — | — | WO | claimed |
| WO-2008017465-A1 | BICYCLIC LACTAM DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-14 | — | — | WO | disclosed |