Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.45 |
| ▸ | APOB | P04114 | 4/20 | 0.41 |
| ▸ | MTTP | P55157 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782468 | 1.00 | POLB (0.46) | POLBL3MBTL1KDM4EGAAHTT | |
| SCHEMBL4782255 | 0.91 | NR1H2 (0.46) | POLBL3MBTL1KDM4EGAAHTT | |
| SCHEMBL4782252 | 0.91 | NR1H2 (0.46) | POLBL3MBTL1KDM4EGAAHTT | |
| SCHEMBL4780011 | 0.90 | NR1H2 (0.45) | POLBL3MBTL1KDM4EGAAHTT | |
| SCHEMBL4780014 | 0.90 | NR1H2 (0.45) | POLBL3MBTL1KDM4EGAAHTT | |
| SCHEMBL4780456 | 0.90 | POLB (0.44) | POLBL3MBTL1KDM4EGAAHTT | |
| SCHEMBL4780458 | 0.90 | POLB (0.44) | POLBL3MBTL1KDM4EGAAHTT | |
| SCHEMBL4782116 | 0.89 | NR1H2 (0.43) | POLBL3MBTL1KDM4EGAAHTT | |
| SCHEMBL4780660 | 0.89 | NR1H2 (0.43) | POLBL3MBTL1KDM4EGAAHTT | |
| SCHEMBL4780662 | 0.89 | NR1H2 (0.43) | POLBL3MBTL1KDM4EGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |