Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 6/20 | 0.53 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | LPL | P06858 | 3/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.42 |
| ▸ | F11 | P03951 | 3/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | P4HB | P07237 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1572955 | 0.84 | HIF1A (0.56) | HIF1AAAK1CA1CA2CA9 | |
| SCHEMBL578525 | 0.84 | HIF1A (0.53) | HIF1AAAK1CA1CA2CA9 | |
| SCHEMBL13606514 | 0.83 | AAK1 (0.57) | HIF1AAAK1CA1CA2CA9 | |
| SCHEMBL5956627 | 0.82 | CA1 (0.54) | HIF1AAAK1CA1CA2CA9 | |
| SCHEMBL28571132 | 0.81 | HIF1A (0.54) | HIF1AAAK1CA1CA2CA9 | |
| SCHEMBL27165341 | 0.80 | SMN1; SMN2 (0.52) | HIF1AAAK1CA1CA2CA9 | |
| SCHEMBL14241985 | 0.80 | HIF1A (0.59) | HIF1AAAK1CA1CA2CA9 | |
| SCHEMBL38657976 | 0.80 | AAK1 (0.52) | HIF1AAAK1CA1CA2CA9 | |
| SCHEMBL473933 | 0.79 | GAA (0.54) | HIF1AAAK1CA1CA2CA9 | |
| SCHEMBL16787740 | 0.79 | AAK1 (0.56) | HIF1AAAK1CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |