Sugi Predict

Sugi Predict / Compounds / SCHEMBL4782689

SCHEMBL4782689

SCHEMBL4782689

O=c1ccc2c(-c3ccc(F)cc3Cl)cc(O)cc2n1-c1c(Cl)cccc1Cl

nearest known ligand 0.76

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ MAPK14 Q16539 20/20 0.76
▸ MAPK11 Q15759 3/20 0.54
▸ MAPK13 O15264 2/20 0.54
▸ MAPK12 P53778 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4732036 0.92 MAPK14 (0.64) MAPK14MAPK11MAPK13MAPK12
SCHEMBL6864369 0.92 MAPK14 (0.71) MAPK14MAPK11MAPK13MAPK12
SCHEMBL6668998 0.87 MAPK14 (1.00) MAPK14MAPK11MAPK13MAPK12
SCHEMBL4783647 0.86 MAPK14 (0.59) MAPK14MAPK11MAPK13MAPK12
SCHEMBL14201925 0.84 MAPK14 (0.57) MAPK14MAPK11MAPK13MAPK12
SCHEMBL4732500 0.82 MAPK14 (0.58) MAPK14MAPK11MAPK13MAPK12
SCHEMBL14203884 0.80 MAPK14 (0.60) MAPK14MAPK11MAPK13MAPK12
SCHEMBL16573718 0.77 MAPK14 (0.72) MAPK14MAPK11
SCHEMBL6666576 0.77 MAPK14 (0.52) MAPK14MAPK11MAPK13MAPK12
SCHEMBL6667548 0.76 MAPK14 (0.61) MAPK14MAPK11MAPK13MAPK12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008053158-A1 INHIBITORS OF P38 MITOGEN-ACTIVATED PROTEIN KINASE CHROMA THERAPEUTICS LTD. (GB) 2008-05-08 — — WO disclosed
WO-2008053158-A1 INHIBITORS OF P38 MITOGEN-ACTIVATED PROTEIN KINASE CHROMA THERAPEUTICS LTD. (GB) 2008-05-08 — — WO disclosed