Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 16/20 | 0.59 |
| ▸ | PLK3 | Q9H4B4 | 11/20 | 0.59 |
| ▸ | BRD4 | O60885 | 3/20 | 0.49 |
| ▸ | PLK2 | Q9NYY3 | 8/20 | 0.45 |
| ▸ | TTK | P33981 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783987 | 0.93 | PLK1 (0.57) | PLK1PLK3BRD4PLK2TTK | |
| SCHEMBL4804359 | 0.93 | PLK1 (0.59) | PLK1PLK3BRD4PLK2TTK | |
| SCHEMBL4782741 | 0.93 | PLK1 (0.59) | PLK1PLK3BRD4PLK2TTK | |
| SCHEMBL4781955 | 0.91 | PLK1 (0.58) | PLK1PLK3BRD4PLK2TTK | |
| SCHEMBL4784278 | 0.91 | PLK1 (0.58) | PLK1PLK3BRD4PLK2TTK | |
| SCHEMBL4783645 | 0.90 | PLK1 (0.56) | PLK1PLK3BRD4PLK2TTK | |
| SCHEMBL4782149 | 0.89 | PLK1 (0.57) | PLK1PLK3BRD4PLK2TTK | |
| SCHEMBL14220999 | 0.86 | PLK1 (0.56) | PLK1PLK3BRD4PLK2TTK | |
| SCHEMBL4731448 | 0.85 | PLK1 (0.54) | PLK1PLK3BRD4PLK2MAPK7 | |
| SCHEMBL4784080 | 0.84 | PLK1 (0.54) | PLK1PLK3BRD4PLK2TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040951-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |
| WO-2008040951-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |