Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3213066 | 0.95 | TDP1 (0.50) | TDP1PTPN1LMNAHPGDPTPN2 | |
| SCHEMBL2934340 | 0.93 | PTPN1 (0.47) | TDP1PTPN1PTPN2KMT2APOLB | |
| SCHEMBL2934077 | 0.85 | PTPN1 (0.46) | PTPN1LMNAPTPN2KMT2APOLB | |
| SCHEMBL2933075 | 0.82 | PTPN1 (0.45) | PTPN1PTPN2POLBTP53ALDH1A1 | |
| SCHEMBL3202520 | 0.82 | PTPN1 (0.48) | PTPN1LMNAPTPN2POLBPKM | |
| SCHEMBL3200992 | 0.82 | PTPN1 (0.45) | PTPN1LMNAHPGDPTPN2HTT | |
| SCHEMBL3216007 | 0.80 | PTPN1 (0.47) | PTPN1PTPN2POLBRAB9AMAPT | |
| SCHEMBL3221264 | 0.80 | PTPN1 (0.47) | TDP1PTPN1PTPN2KMT2APOLB | |
| SCHEMBL3225865 | 0.80 | PTPN1 (0.53) | PTPN1PTPN2POLB | |
| SCHEMBL3213374 | 0.80 | PTPN1 (0.43) | PTPN1LMNAHPGDPTPN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008067527-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE FOR THE TREATMENT OF MUSCLE ATROPHY AND RELATED DISORDERS | NOVARTIS AG (CH) | 2008-06-05 | — | — | WO | disclosed |