Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM3 | Q86V86 | 11/20 | 0.39 |
| ▸ | PIM1 | P11309 | 11/20 | 0.39 |
| ▸ | AKT1 | P31749 | 4/20 | 0.37 |
| ▸ | CDK2 | P24941 | 4/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 8/20 | 0.36 |
| ▸ | CDC7 | O00311 | 6/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.34 |
| ▸ | AURKA | O14965 | 3/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.34 |
| ▸ | PRKACA | P17612 | 3/20 | 0.34 |
| ▸ | CLK2 | P49760 | 3/20 | 0.34 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | PRKX | P51817 | 3/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.34 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4893246 | 0.78 | AKT1 (0.41) | PIM3PIM1AKT1CDK2PIM2 | |
| SCHEMBL4902461 | 0.78 | AKT1 (0.41) | PIM3PIM1AKT1CDK2PIM2 | |
| SCHEMBL4895589 | 0.72 | AKT1 (0.47) | PIM3PIM1AKT1CDK2PIM2 | |
| SCHEMBL4900504 | 0.72 | AKT1 (0.47) | PIM3PIM1AKT1CDK2PIM2 | |
| SCHEMBL4901166 | 0.71 | AKT1 (0.44) | PIM3PIM1AKT1CDK2PIM2 | |
| SCHEMBL4901159 | 0.71 | AKT1 (0.44) | PIM3PIM1AKT1CDK2PIM2 | |
| SCHEMBL4781631 | 0.66 | AKT1 (0.43) | PIM3PIM1AKT1CDK2PIM2 | |
| SCHEMBL4781629 | 0.66 | AKT1 (0.43) | PIM3PIM1AKT1CDK2PIM2 | |
| SCHEMBL4899369 | 0.66 | AKT1 (0.50) | PIM3PIM1AKT1CDK2PIM2 | |
| SCHEMBL4783228 | 0.65 | AKT1 (0.41) | PIM3PIM1AKT1CDK2PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008036308-A2 | AMINO-SUBSTITUTED HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-03-27 | — | — | WO | disclosed |