Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 8/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.32 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4557843 | 0.98 | PTPN1 (0.40) | PTPN1PTPN2EPHX2PPARGGAA | |
| SCHEMBL3224722 | 0.90 | PTPN1 (0.48) | PTPN1PTPN2EPHX2PPARGGAA | |
| SCHEMBL3221800 | 0.88 | PTPN1 (0.47) | PTPN1PTPN2 | |
| SCHEMBL4783346 | 0.86 | PTPN1 (0.36) | PTPN1PTPN2 | |
| SCHEMBL4557840 | 0.84 | PTPN1 (0.35) | PTPN1PTPN2 | |
| SCHEMBL3221773 | 0.81 | PTPN1 (0.50) | PTPN1PTPN2 | |
| SCHEMBL3220627 | 0.80 | PTPN1 (0.48) | PTPN1PTPN2CHRM1 | |
| SCHEMBL2937678 | 0.78 | PTPN1 (0.47) | PTPN1PTPN2ALDH1A1 | |
| SCHEMBL3214725 | 0.75 | PTPN1 (0.48) | PTPN1PTPN2PPARGKDM4EALDH1A1 | |
| SCHEMBL3210005 | 0.74 | PTPN1 (0.51) | PTPN1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008067527-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE FOR THE TREATMENT OF MUSCLE ATROPHY AND RELATED DISORDERS | NOVARTIS AG (CH) | 2008-06-05 | — | — | WO | disclosed |