Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 11/20 | 0.67 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.67 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.67 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.67 |
| ▸ | PDCD1 | Q15116 | 7/20 | 0.61 |
| ▸ | CD274 | Q9NZQ7 | 7/20 | 0.61 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.57 |
| ▸ | MTOR | P42345 | 1/20 | 0.57 |
| ▸ | ATR | Q13535 | 6/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.54 |
| ▸ | ATRIP | Q8WXE1 | 5/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15805508 | 0.89 | PIK3CB (0.75) | PIK3CBPIK3CDPIK3CAPIK3R1PIK3CG | |
| SCHEMBL29434924 | 0.86 | PIK3CB (0.89) | PIK3CBPIK3CDPIK3CAPIK3R1PIK3CG | |
| SCHEMBL4588794 | 0.86 | PIK3CB (0.89) | PIK3CBPIK3CDPIK3CAPIK3R1PIK3CG | |
| SCHEMBL4730034 | 0.86 | PIK3CB (0.89) | PIK3CBPIK3CDPIK3CAPIK3R1PIK3CG | |
| SCHEMBL29434920 | 0.86 | PIK3CB (0.89) | PIK3CBPIK3CDPIK3CAPIK3R1PIK3CG | |
| SCHEMBL15029392 | 0.85 | PDCD1 (0.64) | PIK3CBPIK3CDPIK3CAPIK3R1PIK3CG | |
| Hydrochloric Acid SCHEMBL28720152 | 0.85 | PIK3CB (0.87) | PIK3CBPIK3CDPIK3CAPIK3R1PIK3CG | |
| SCHEMBL4585104 | 0.84 | PDCD1 (0.62) | PIK3CBPIK3CDPIK3CAPIK3R1PIK3CG | |
| SCHEMBL10124235 | 0.84 | PDCD1 (0.64) | PIK3CBPIK3CDPIK3CAPIK3R1PIK3CG | |
| SCHEMBL10124206 | 0.84 | PDCD1 (0.64) | PIK3CBPIK3CDPIK3CAPIK3R1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008032060-A1 | 4-BENZIMIDAZ0LYL-6-M0RPH0LIN0-2-PIPERAZINYLPYRIMIDINE DERIVATIVES AS P13K AND MTOR INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | disclosed |