Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 8/20 | 0.60 |
| ▸ | MAOA | P21397 | 5/20 | 0.50 |
| ▸ | MAOB | P27338 | 5/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.44 |
| ▸ | SCN1A | P35498 | 3/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.44 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Midaglizole SCHEMBL30029057 | 0.90 | NISCH (0.74) | NISCHMAOAMAOBCHRM2SLC6A2 | |
| Midaglizole SCHEMBL114554 | 0.90 | NISCH (0.74) | NISCHMAOAMAOBCHRM2SLC6A2 | |
| Midaglizole SCHEMBL9403180 | 0.89 | NISCH (0.72) | NISCHMAOAMAOBCHRM2SLC6A2 | |
| Midaglizole SCHEMBL752697 | 0.89 | NISCH (0.72) | NISCHMAOAMAOBCHRM2SLC6A2 | |
| SCHEMBL7548321 | 0.83 | NISCH (0.66) | NISCHMAOAMAOBCHRM2SLC6A2 | |
| SCHEMBL7547511 | 0.79 | NISCH (0.57) | NISCHMAOAMAOBCHRM2SLC6A2 | |
| SCHEMBL7555329 | 0.79 | NISCH (0.57) | NISCHMAOAMAOBCHRM2SLC6A2 | |
| SCHEMBL7548764 | 0.78 | NISCH (0.56) | NISCHMAOAMAOBCHRM2SLC6A2 | |
| SCHEMBL7547171 | 0.77 | NISCH (1.00) | NISCHMAOAMAOBADRA2BLMNA | |
| SCHEMBL7553919 | 0.77 | NISCH (0.54) | NISCHMAOAMAOBCHRM2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008041090-A1 | MALANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONIST PYRIDINONES | PFIZER LIMITED (GB) | 2008-04-10 | — | — | WO | disclosed |