Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 9/20 | 0.43 |
| ▸ | APOB | P04114 | 6/20 | 0.41 |
| ▸ | MTTP | P55157 | 6/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | WNT3 | P56703 | 1/20 | 0.35 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784075 | 1.00 | NR1H2 (0.43) | NR1H2APOBMTTPNR1H3HDAC2 | |
| SCHEMBL4783212 | 0.89 | NR1H2 (0.46) | NR1H2APOBMTTPNR1H3KDM4E | |
| SCHEMBL4783220 | 0.89 | NR1H2 (0.46) | NR1H2APOBMTTPNR1H3KDM4E | |
| SCHEMBL4780303 | 0.86 | GRIA2 (0.46) | NR1H2APOBMTTPNR1H3KDM4E | |
| SCHEMBL4780306 | 0.86 | GRIA2 (0.46) | NR1H2APOBMTTPNR1H3KDM4E | |
| SCHEMBL4782252 | 0.86 | NR1H2 (0.46) | NR1H2APOBMTTPNR1H3KDM4E | |
| SCHEMBL4782255 | 0.86 | NR1H2 (0.46) | NR1H2APOBMTTPNR1H3KDM4E | |
| SCHEMBL4780660 | 0.85 | NR1H2 (0.43) | NR1H2APOBMTTPNR1H3KDM4E | |
| SCHEMBL4782116 | 0.85 | NR1H2 (0.43) | NR1H2APOBMTTPNR1H3KDM4E | |
| SCHEMBL4780662 | 0.85 | NR1H2 (0.43) | NR1H2APOBMTTPNR1H3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |