Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 9/20 | 0.43 |
| ▸ | APOB | P04114 | 4/20 | 0.41 |
| ▸ | MTTP | P55157 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.37 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.37 |
| ▸ | ITGAL | P20701 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | WNT3 | P56703 | 1/20 | 0.35 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784118 | 1.00 | NR1H2 (0.43) | NR1H2APOBMTTPCYP2C19GRIA2 | |
| SCHEMBL4782252 | 0.90 | NR1H2 (0.46) | NR1H2APOBMTTPKDM4EPOLB | |
| SCHEMBL4782255 | 0.90 | NR1H2 (0.46) | NR1H2APOBMTTPKDM4EPOLB | |
| SCHEMBL4780011 | 0.90 | NR1H2 (0.45) | NR1H2APOBMTTPKDM4EPOLB | |
| SCHEMBL4780014 | 0.90 | NR1H2 (0.45) | NR1H2APOBMTTPKDM4EPOLB | |
| SCHEMBL4780662 | 0.89 | NR1H2 (0.43) | NR1H2APOBMTTPCYP2C19GRIA2 | |
| SCHEMBL4782122 | 0.89 | NR1H2 (0.43) | NR1H2APOBMTTPKDM4EPOLB | |
| SCHEMBL4782116 | 0.89 | NR1H2 (0.43) | NR1H2APOBMTTPKDM4EPOLB | |
| SCHEMBL4780660 | 0.89 | NR1H2 (0.43) | NR1H2APOBMTTPCYP2C19GRIA2 | |
| SCHEMBL4782468 | 0.88 | POLB (0.46) | NR1H2APOBMTTPKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |