Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 14/20 | 0.56 |
| ▸ | PLK3 | Q9H4B4 | 11/20 | 0.56 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.47 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.47 |
| ▸ | PLK2 | Q9NYY3 | 10/20 | 0.45 |
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | TAF1 | P21675 | 1/20 | 0.41 |
| ▸ | VRK1 | Q99986 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4798215 | 0.91 | PLK1 (0.55) | PLK1PLK3PIP4K2APIP4K2BPLK2 | |
| SCHEMBL4779878 | 0.90 | PLK1 (0.54) | PLK1PLK3PIP4K2APIP4K2BPLK2 | |
| SCHEMBL4729390 | 0.90 | PLK1 (0.56) | PLK1PLK3PLK2BRD4MAPK7 | |
| SCHEMBL4782849 | 0.89 | PLK1 (0.60) | PLK1PLK3PIP4K2APIP4K2BPLK2 | |
| SCHEMBL4784197 | 0.88 | PLK1 (0.56) | PLK1PLK3PLK2BRD4MAPK7 | |
| SCHEMBL4729262 | 0.87 | PLK1 (0.56) | PLK1PLK3PIP4K2APIP4K2BPLK2 | |
| SCHEMBL4784001 | 0.87 | PLK1 (0.61) | PLK1PLK3PIP4K2APIP4K2BPLK2 | |
| SCHEMBL4782049 | 0.87 | PLK1 (0.55) | PLK1PLK3PIP4K2APIP4K2BPLK2 | |
| SCHEMBL14221001 | 0.86 | PLK1 (0.54) | PLK1PLK3PLK2BRD4MAPK7 | |
| SCHEMBL14221000 | 0.86 | PLK1 (0.51) | PLK1PLK3PIP4K2APIP4K2BPLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040951-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |
| WO-2008040951-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |