Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.59 |
| ▸ | FLT4 | P35916 | 1/20 | 0.59 |
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | HRH2 | P25021 | 1/20 | 0.52 |
| ▸ | HTR1D | P28221 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | HTR5A | P47898 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12325149 | 0.78 | BRD4 (0.64) | JAK2MKNK1EGFREIF2AK2BRD4 | |
| SCHEMBL15360086 | 0.78 | HRH4 (0.70) | AURKAFLT4HRH4HRH3ADRA2B | |
| SCHEMBL28322770 | 0.78 | JAK2 (0.71) | AURKAJAK2FLT3MKNK1EGFR | |
| SCHEMBL20012926 | 0.75 | MKNK1 (0.62) | AURKAFLT4HRH4JAK2FLT3 | |
| SCHEMBL5256958 | 0.75 | AURKA (1.00) | AURKAFLT4HRH4HRH3MKNK1 | |
| SCHEMBL29997962 | 0.75 | HRH4 (0.65) | HRH4HRH3HTR6 | |
| SCHEMBL2190955 | 0.75 | HRH4 (0.65) | HRH4HRH3HTR6 | |
| SCHEMBL1588697 | 0.74 | HRH4 (1.00) | HRH4HRH3ADRA2BADRA2CSLC6A2 | |
| SCHEMBL27020409 | 0.74 | EGFR (0.64) | AURKAJAK2FLT3MKNK1ADRA2C | |
| SCHEMBL4074997 | 0.74 | ZAP70 (0.53) | AURKAFLT4HRH4HRH3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060766-A2 | HISTAMINE H4 RECEPTOR LIGANDS FOR USE IN PAIN TREATMENT | ABBOTT LABORATORIES (US) | 2008-05-22 | — | — | WO | disclosed |