Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | CALCRL | Q16602 | 11/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | RAMP1 | O60894 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782585 | 0.88 | PIK3CD (0.45) | CALCRLRAMP1 | |
| SCHEMBL14205003 | 0.87 | CALCRL (0.41) | CALCRLRAMP1 | |
| SCHEMBL14204999 | 0.87 | KDM4E (0.44) | CHRM4CHRM1MEN1ALDH1A1MAPT | |
| SCHEMBL14204998 | 0.84 | KMT2A (0.45) | MEN1ALDH1A1MAPTKMT2ATSHR | |
| SCHEMBL14204676 | 0.83 | CALCRL (0.47) | CALCRLRAMP1 | |
| SCHEMBL14204681 | 0.83 | CALCRL (0.41) | CALCRLRAMP1 | |
| SCHEMBL14205348 | 0.83 | CALCRL (0.40) | CHRM4CHRM1CALCRLRAMP1 | |
| SCHEMBL14204691 | 0.83 | CALCRL (0.41) | CALCRLRAMP1 | |
| SCHEMBL14205004 | 0.83 | CALCRL (0.41) | CHRM4CHRM1CALCRLRAMP1 | |
| SCHEMBL14205743 | 0.83 | HTR2C (0.43) | CALCRLRAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008070014-A2 | BIARYL KETONE-SUBSTITUTED PIPERIDINES | NEUROGEN CORPORATION (US) | 2008-06-12 | — | — | WO | disclosed |
| WO-2008070014-A2 | BIARYL KETONE-SUBSTITUTED PIPERIDINES | NEUROGEN CORPORATION (US) | 2008-06-12 | — | — | WO | disclosed |
| WO-2008060568-A2 | AMIDE-SUBSTITUTED ARYL PIPERIDINES | NEUROGEN CORPORATION (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008060568-A2 | AMIDE-SUBSTITUTED ARYL PIPERIDINES | NEUROGEN CORPORATION (US) | 2008-05-22 | — | — | WO | disclosed |