Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.55 |
| ▸ | APP | P05067 | 2/20 | 0.48 |
| ▸ | BACE2 | Q9Y5Z0 | 8/20 | 0.48 |
| ▸ | CTSD | P07339 | 7/20 | 0.48 |
| ▸ | REN | P00797 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4785029 | 0.94 | BACE1 (0.55) | BACE1APPBACE2CTSDREN | |
| SCHEMBL4242565 | 0.84 | BACE1 (0.70) | BACE1APPBACE2CTSDREN | |
| SCHEMBL4733764 | 0.83 | BACE1 (0.60) | BACE1APPBACE2CTSDREN | |
| SCHEMBL4785926 | 0.82 | BACE1 (0.72) | BACE1BACE2CTSDREN | |
| SCHEMBL4735505 | 0.82 | BACE1 (0.51) | BACE1APPBACE2CTSDREN | |
| SCHEMBL4109626 | 0.81 | BACE1 (0.58) | BACE1APPBACE2CTSDREN | |
| SCHEMBL7886978 | 0.81 | BACE1 (0.66) | BACE1APPBACE2CTSDREN | |
| SCHEMBL4785838 | 0.81 | BACE1 (0.55) | BACE1BACE2CTSDREN | |
| SCHEMBL4786269 | 0.81 | BACE1 (0.61) | BACE1APPBACE2CTSDREN | |
| SCHEMBL4855109 | 0.80 | BACE1 (0.49) | BACE1APPBACE2CTSDREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076044-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |