Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 15/20 | 0.60 |
| ▸ | PLK3 | Q9H4B4 | 5/20 | 0.60 |
| ▸ | BRD4 | O60885 | 5/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | PLK2 | Q9NYY3 | 3/20 | 0.44 |
| ▸ | GALR1 | P47211 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PRKCG | P05129 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4800861 | 0.93 | PLK1 (0.60) | PLK1PLK3BRD4PSEN1PSEN2 | |
| SCHEMBL4730833 | 0.92 | PLK1 (0.63) | PLK1PLK3BRD4JAK2JAK1 | |
| SCHEMBL4731448 | 0.91 | PLK1 (0.54) | PLK1PLK3BRD4PLK2RPS6KA3 | |
| SCHEMBL4784233 | 0.90 | PLK1 (0.62) | PLK1PLK3BRD4PSEN1PSEN2 | |
| SCHEMBL4783694 | 0.90 | PLK1 (0.54) | PLK1PLK3BRD4PLK2RPS6KA3 | |
| SCHEMBL4782180 | 0.90 | PLK1 (0.58) | PLK1PLK3BRD4JAK2JAK1 | |
| SCHEMBL4781788 | 0.88 | PLK1 (0.60) | PLK1PLK3BRD4PSEN1PSEN2 | |
| SCHEMBL4781914 | 0.88 | PLK1 (0.52) | PLK1PLK3BRD4PLK2RPS6KA3 | |
| SCHEMBL4730180 | 0.88 | PLK1 (0.54) | PLK1PLK3BRD4PLK2RPS6KA3 | |
| SCHEMBL4844864 | 0.86 | PLK1 (0.52) | PLK1PLK3BRD4PLK2RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040951-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2008-04-10 | — | — | WO | disclosed |