Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | SLC22A12 | Q96S37 | 8/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.45 |
| ▸ | WNT3 | P56703 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.44 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.44 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.44 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4732746 | 0.90 | CA1 (0.56) | NR1H2CA1CA2SLC22A12MEN1 | |
| SCHEMBL4785610 | 0.88 | NR1H2 (0.54) | NR1H2SLC22A12MEN1KMT2ASFRP1 | |
| SCHEMBL4784035 | 0.87 | NR1H2 (0.46) | NR1H2SLC22A12MEN1KMT2ASFRP1 | |
| SCHEMBL4782504 | 0.87 | NR1H2 (0.55) | NR1H2SLC22A12SFRP1WNT3CYP2C9 | |
| SCHEMBL4783738 | 0.87 | NR1H2 (0.55) | NR1H2CA1CA2SLC22A12MEN1 | |
| SCHEMBL4731532 | 0.85 | NR1H2 (0.43) | NR1H2SLC22A12MEN1KMT2ASFRP1 | |
| SCHEMBL4733742 | 0.84 | NR1H2 (0.55) | NR1H2MEN1KMT2ASFRP1WNT3 | |
| SCHEMBL4784546 | 0.84 | NR1H2 (0.46) | NR1H2CA1CA2SLC22A12MEN1 | |
| SCHEMBL4784211 | 0.83 | NR1H2 (0.48) | NR1H2SLC22A12MEN1KMT2ASFRP1 | |
| SCHEMBL4784216 | 0.82 | NR1H2 (0.49) | NR1H2SLC22A12MEN1KMT2ASFRP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |