Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 11/20 | 0.55 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | UGCG | Q16739 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4511502 | 0.94 | MC4R (0.61) | MC4RMEN1KMT2A | |
| SCHEMBL4528843 | 0.87 | MC4R (0.69) | MC4RTNKSTNKS2MEN1KMT2A | |
| SCHEMBL4785586 | 0.86 | MC4R (0.41) | MC4RTNKSTNKS2PTGDR2LMNA | |
| SCHEMBL4532255 | 0.82 | MC4R (0.67) | MC4R | |
| SCHEMBL4511510 | 0.81 | MC4R (0.45) | MC4R | |
| SCHEMBL4529443 | 0.80 | MC4R (0.66) | MC4R | |
| SCHEMBL4519844 | 0.79 | MC4R (0.69) | MC4R | |
| SCHEMBL4518970 | 0.79 | MC4R (0.64) | MC4R | |
| SCHEMBL13790245 | 0.78 | MC4R (0.64) | MC4R | |
| SCHEMBL4506983 | 0.77 | MC4R (0.68) | MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1417190-B1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC (US) | 2008-10-22 | — | — | EP | disclosed |