Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CCR5 | P51681 | 7/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4675599 | 0.88 | HDAC1 (0.69) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL4672585 | 0.78 | HDAC1 (0.65) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL4676323 | 0.76 | HDAC1 (0.64) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL4677136 | 0.76 | HDAC1 (0.56) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL4673153 | 0.71 | HDAC1 (0.67) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| Zabadinostat SCHEMBL4785187 | 0.71 | HDAC1 (0.77) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL4675067 | 0.71 | HDAC1 (0.69) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| Zabadinostat SCHEMBL29678731 | 0.71 | HDAC1 (0.77) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL8240951 | 0.70 | HDAC1 (0.57) | HDAC1HDAC3HDAC2HDAC4HDAC7 | |
| SCHEMBL10092882 | 0.70 | HDAC1 (0.49) | HDAC1HDAC3HDAC2HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954690-A1 | BENZAMIDE COMPOUNDS USEFUL AS HISTONE DEACETYLASE INHIBITORS | Astra Zeneca AB (SE) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007045844-A1 | BENZAMIDE COMPOUNDS USEFUL AS HISTONE DEACETYLASE INHIBITORS | ASTRAZENECA AB (SE) | 2007-04-26 | — | — | WO | disclosed |