SCHEMBL4786208

SCHEMBL4786208

Cc1ccc(C(=O)N2CCC(c3ccc(C(=O)NC4CC4)cc3)CC2)cc1NS(C)(=O)=O.Cc1ccc(C(=O)N2CCC(c3ccc(OS(C)(=O)=O)cc3)CC2)cc1NS(C)(=O)=O.N#Cc1ccc(C2CCN(C(=O)c3ccc(Cl)c(NS(=O)(=O)c4ccccc4F)c3)CC2)cc1

nearest known ligand 0.53

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
FASN P49327 20/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4168163 0.84 FASN (0.58) FASN
SCHEMBL4180429 0.84 FASN (0.56) FASN
SCHEMBL4171986 0.78 FASN (0.76) FASN
SCHEMBL4786209 0.77 FASN (0.56) FASN
SCHEMBL4169825 0.77 FASN (0.78) FASN
SCHEMBL4168172 0.76 FASN (0.59) FASN
SCHEMBL4177248 0.76 FASN (0.57) FASN
SCHEMBL4169811 0.76 FASN (0.59) FASN
SCHEMBL13890622 0.75 FASN (0.58) FASN
SCHEMBL4183291 0.75 FASN (0.55) FASN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008075070-A1 SULFONAMIDE DERIVATIVES FOR THERAPEUTIC USE AS FATTY ACID SYNTHASE INHIBITORS ASTRAZENECA AB (SE) 2008-06-26 WO disclosed