Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GNRHR | P30968 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4233364 | 0.97 | TOP2A (0.35) | TOP2ALMNANPSR1HSD17B10NPC1 | |
| SCHEMBL4228796 | 0.90 | KDM4E (0.35) | LMNANPSR1HSD17B10GNRHRHPGD | |
| SCHEMBL13743595 | 0.89 | GNRHR (0.34) | LMNANPSR1HSD17B10GNRHRHPGD | |
| SCHEMBL13743435 | 0.89 | GNRHR (0.35) | LMNANPSR1HSD17B10GNRHRHPGD | |
| SCHEMBL4237338 | 0.88 | GNRHR (0.34) | LMNANPSR1HSD17B10GNRHRCACNA1F | |
| SCHEMBL4236457 | 0.88 | SYK (0.36) | GNRHRHPGDTSHRCACNA1FCHRM4 | |
| SCHEMBL4685725 | 0.88 | GNRHR (0.32) | GNRHRCACNA1FCHRM4ADORA3CHRM1 | |
| SCHEMBL4226409 | 0.87 | IRAK4 (0.35) | GNRHRHPGDCACNA1FCHRM4ADORA3 | |
| SCHEMBL4233435 | 0.86 | GNRHR (0.35) | LMNANPSR1HSD17B10GNRHRCACNA1F | |
| SCHEMBL4231634 | 0.86 | GNRHR (0.42) | LMNANPC1RAB9ASMN1; SMN2GNRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896465-A1 | HETEROCYCLIC NON-PEPTIDE GNRH ANTAGONISTS | Takeda Cambridge Limited (GB) | 2008-03-12 | — | — | EP | disclosed |
| WO-2007000582-A1 | HETEROCYCLIC NON-PEPTIDE GNRH ANTAGONISTS | TAKEDA CAMBRIDGE LIMITED (GB) | 2007-01-04 | — | — | WO | disclosed |