Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4792073 | 0.74 | IDO1 (0.53) | KDM4ETDP1HTTMAPK1HPGD | |
| SCHEMBL1870141 | 0.74 | MAPT (0.50) | KDM4EHTTPOLB | |
| SCHEMBL11582786 | 0.72 | FGFR1 (0.50) | KDM4ETDP1HTTHPGDHSD17B10 | |
| Water SCHEMBL11581337 | 0.71 | FGFR1 (0.49) | KDM4ETDP1HTTHPGDHSD17B10 | |
| SCHEMBL29485626 | 0.71 | KDM4E (0.45) | KDM4EMAPK1HPGDHSD17B10ALDH1A1 | |
| SCHEMBL1370906 | 0.71 | KDM4E (0.45) | KDM4EMAPK1HPGDHSD17B10ALDH1A1 | |
| SCHEMBL18922383 | 0.71 | KDM4E (0.53) | KDM4EHTTMAPK1ALDH1A1POLB | |
| SCHEMBL28182837 | 0.69 | KDM4E (0.44) | KDM4EMAPK1HPGDHSD17B10ALDH1A1 | |
| SCHEMBL12677712 | 0.68 | USP7 (0.31) | SMN1; SMN2 | |
| SCHEMBL4513269 | 0.68 | KDM4E (0.46) | KDM4ETDP1HTTMAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4129653-A | CARDIOVASCULAR, ANTIASTHMATIC | ORTHO PHARMACEUTICAL CORPORATION (US) | 1978-12-12 | — | — | US | claimed |
| CN-105859727-A | Method for preparing 1-substituted pyrrolo[1,5-c]quinazoline framework compounds through copper catalysis | 江西师范大学 | 2016-08-17 | — | — | CN | disclosed |
| CN-103130810-B | Synthesis method of pyrrolo[1,5-c] quinazoline compounds | UNIV HENAN NORMAL | 2015-02-25 | — | — | CN | disclosed |
| CN-103130810-B | Synthesis method of pyrrolo[1,5-c] quinazoline compounds | UNIV HENAN NORMAL | 2015-02-25 | — | — | CN | disclosed |
| CN-103130810-A | Synthesis method of pyrrolo[1,5-c] quinazoline compounds | UNIV HENAN NORMAL | 2013-06-05 | — | — | CN | disclosed |
| CN-103130810-A | Synthesis method of pyrrolo[1,5-c] quinazoline compounds | UNIV HENAN NORMAL | 2013-06-05 | — | — | CN | disclosed |
| WO-2008144483-A2 | AGENTS FOR TREATING DISORDERS INVOLVING MODULATION OF RYANODINE RECEPTORS | ARMGO PHARMA, INC. (US) | 2008-11-27 | — | — | WO | disclosed |
| EP-0446141-B1 | Imidazo[1,2-c]quinazoline derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1995-01-18 | — | — | EP | disclosed |
| US-4129653-A | CARDIOVASCULAR, ANTIASTHMATIC | ORTHO PHARMACEUTICAL CORPORATION (US) | 1978-12-12 | — | — | US | disclosed |
| US-4129653-A | CARDIOVASCULAR, ANTIASTHMATIC | ORTHO PHARMACEUTICAL CORPORATION (US) | 1978-12-12 | — | — | US | disclosed |