Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 5/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | BMX | P51813 | 1/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.38 |
| ▸ | CDK8 | P49336 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 4/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788874 | 0.92 | KMT2A (0.43) | LCKMAPK14KDRDDR1CDK8 | |
| SCHEMBL4788641 | 0.89 | LCK (0.49) | LCKMAPK14KDRBMXDDR1 | |
| SCHEMBL4789346 | 0.84 | LCK (0.49) | LCKMAPK14KDRCDK8KMT2A | |
| SCHEMBL4788647 | 0.80 | LCK (0.46) | LCKMAPK14KDRBMXDDR1 | |
| SCHEMBL4790218 | 0.79 | BMX (0.49) | LCKMAPK14KDRBMXDDR1 | |
| SCHEMBL4787603 | 0.78 | RAF1 (0.47) | LCKMAPK14KDRBMXDDR1 | |
| SCHEMBL4789699 | 0.78 | RAF1 (0.47) | LCKMAPK14KDRBMXDDR1 | |
| SCHEMBL4788649 | 0.76 | BMX (0.47) | LCKMAPK14KDRBMXDDR1 | |
| SCHEMBL4787775 | 0.76 | RXFP1 (0.51) | LCKMAPK14KDRBMXDDR1 | |
| SCHEMBL4788889 | 0.76 | BMX (0.53) | LCKMAPK14KDRBMXDDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |