⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19675434 | 0.76 | — | — | |
| SCHEMBL22292622 | 0.70 | — | — | |
| SCHEMBL526288 | 0.62 | — | — | |
| SCHEMBL12370560 | 0.62 | — | — | |
| SCHEMBL10981439 | 0.60 | — | — | |
| Hydrochloric Acid SCHEMBL27815894 | 0.60 | — | — | |
| Fluoride SCHEMBL27932909 | 0.60 | — | — | |
| SCHEMBL2310070 | 0.60 | — | — | |
| SCHEMBL14781231 | 0.59 | — | — | |
| SCHEMBL3116028 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970224-B1 | TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS | ONYX THERAPEUTICS INC (US) | 2017-09-06 | — | — | EP | disclosed |
| WO-2015037939-A1 | A NOVEL PHTALAZINONE DERIVATIVES AND MANUFACTURING PROCESS THEREOF | ILDONG PHARM CO., LTD. (KR) | 2015-03-19 | — | — | WO | disclosed |
| WO-2014152127-A1 | DIPEPTIDE AND TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS | ONYX THERAPEUTICS, INC. (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2014152134-A1 | TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS | ONYX THERAPEUTICS, INC. (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2008132091-A1 | A LITHOGRAPHIC PRINTING PLATE PRECURSOR | AGFA GRAPHICS NV (BE) | 2008-11-06 | — | — | WO | disclosed |
| US-4587251-A | Indolo[2,3-a]quinolizine and indolo[2,3-g]cyclopent[a]indolizine derivatives, compositions and methods employing them for treating ulcers | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1986-05-06 | — | — | US | disclosed |
| US-4563464-A | 2-Azabicyclo(2.2.2)octane derivatives and their use as immunosuppressive agents | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1986-01-07 | — | — | US | disclosed |
| EP-0132964-A2 | 2-Azabicyclo[2.2.2]octane derivatives | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1985-02-13 | — | — | EP | disclosed |
| EP-0130823-A2 | Indolo [2,3-a]quinolizine and indolo[2,3-g]cyclopent[a]indolizine derivatives | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1985-01-09 | — | — | EP | disclosed |