Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 11/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.49 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.48 |
| ▸ | YES1 | P07947 | 1/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL263327 | 0.90 | AURKA (0.54) | SRCPDGFRBSIGMAR1NEK1YES1 | |
| SCHEMBL266294 | 0.87 | MEN1 (0.57) | SRCPDGFRBMEN1NPC1LMNA | |
| SCHEMBL264216 | 0.85 | SRC (0.54) | SRCPDGFRBSIGMAR1NEK1YES1 | |
| SCHEMBL266847 | 0.85 | SYK (0.55) | SRCPDGFRBSYKYES1EPHB4 | |
| SCHEMBL267040 | 0.85 | EGFR (0.58) | SRCPDGFRBSYKYES1EPHB4 | |
| Trifluoroacetic Acid SCHEMBL264883 | 0.83 | FAM20C (0.49) | SRCPDGFRBMEN1NPC1LMNA | |
| SCHEMBL267069 | 0.82 | SYK (0.49) | SRCPDGFRBSYKYES1EPHB4 | |
| Trifluoroacetic Acid SCHEMBL267068 | 0.81 | SYK (0.50) | SRCPDGFRBMAPK1SYKYES1 | |
| Trifluoroacetic Acid SCHEMBL265082 | 0.81 | EGFR (0.50) | SRCPDGFRBSYKYES1EPHB4 | |
| SCHEMBL3520398 | 0.80 | JAK2 (0.57) | NEK1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904479-A2 | NOVEL 2,4-DIANILINOPYRIMIDINE DERIVATIVES, THE PREPARATION THEREOF, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND, IN PARTICULAR, AS IKK INHIBITORS | Sanofi-Aventis (FR) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007006926-A2 | NOVEL 2,4-DIANILINOPYRIMIDINE DERIVATIVES, THE PREPARATION THEREOF, THEIR USE AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND, IN PARTICULAR, AS IKK INHIBITORS | SANOFI-AVENTIS (FR) | 2007-01-18 | — | — | WO | disclosed |