Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 5/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 14/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.54 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13982353 | 0.89 | ATR (0.50) | ATRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL360996 | 0.85 | PIK3CD (0.69) | ATRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL4788956 | 0.79 | ATR (0.61) | ATRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL4754345 | 0.79 | SMN1; SMN2 (0.47) | — | |
| SCHEMBL13982278 | 0.78 | ATR (0.58) | ATRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL4754666 | 0.78 | PIK3CA (0.65) | ATRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL13982550 | 0.78 | ATR (0.59) | ATRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL13982352 | 0.78 | ATR (0.61) | ATRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1164345 | 0.77 | PIK3CD (0.84) | PIK3CDPIK3CAPIK3CBPIK3CGMTOR | |
| SCHEMBL4789273 | 0.77 | ATR (0.59) | ATRPIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008152387-A1 | QUINAZOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008152387-A1 | QUINAZOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-12-18 | — | — | WO | disclosed |