Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 17/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.65 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3058046 | 1.00 | HRH3 (0.74) | HRH3KCNH2DRD2DRD3 | |
| SCHEMBL3070874 | 0.86 | HRH3 (0.71) | HRH3KCNH2 | |
| SCHEMBL3057657 | 0.85 | HRH3 (0.74) | HRH3KCNH2 | |
| SCHEMBL4754762 | 0.85 | HRH3 (1.00) | HRH3KCNH2 | |
| SCHEMBL3062819 | 0.80 | HRH3 (0.66) | HRH3KCNH2 | |
| SCHEMBL3058127 | 0.80 | HRH3 (0.72) | HRH3KCNH2 | |
| SCHEMBL3063479 | 0.80 | HRH3 (0.69) | HRH3KCNH2 | |
| Abt-288 SCHEMBL2409486 | 0.79 | HRH3 (1.00) | HRH3KCNH2 | |
| Abt-288 SCHEMBL3691125 | 0.79 | HRH3 (1.00) | HRH3KCNH2 | |
| Abt-288 SCHEMBL2406947 | 0.79 | HRH3 (1.00) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001885-A2 | OCTAHYDRO-PYRROLO[3,4-B]PYRROLE DERIVATIVES | Abbott Laboratories (US) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007100990-A2 | OCTAHYDRO-PYRROLO[3,4-B] PYRROLE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2007-09-07 | — | — | WO | disclosed |