Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.58 |
| ▸ | LCK | P06239 | 13/20 | 0.58 |
| ▸ | HCK | P08631 | 11/20 | 0.58 |
| ▸ | SRC | P12931 | 10/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4175964 | 0.88 | KDR (0.74) | KDRLCKHCKSRCNPC1 | |
| SCHEMBL3587794 | 0.76 | LCK (0.81) | KDRLCKHCKSRCNPC1 | |
| SCHEMBL4179831 | 0.76 | LCK (0.75) | KDRLCKHCKSRCNPC1 | |
| SCHEMBL13503283 | 0.75 | LCK (0.85) | KDRLCKHCKSRCNPC1 | |
| SCHEMBL4170453 | 0.74 | LCK (0.77) | KDRLCKHCKSRCNPC1 | |
| SCHEMBL4168156 | 0.74 | LCK (0.87) | KDRLCKHCKSRC | |
| SCHEMBL4177466 | 0.73 | LCK (1.00) | KDRLCKHCKSRC | |
| SCHEMBL4164403 | 0.72 | LCK (0.77) | KDRLCKHCKSRCNPC1 | |
| SCHEMBL4170364 | 0.72 | LCK (0.74) | KDRLCKHCKSRCNPC1 | |
| SCHEMBL4171810 | 0.72 | LCK (0.71) | KDRLCKHCKSRCNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1993552-A2 | USE OF PYRAZOLO[1,5A]PYRIMIDIN-7-YL AMINE DERIVATIVES IN THE TREATMENT OF NEUROLOGICAL DISORDERS | Novartis AG (CH) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007103432-A2 | USE OF PYRAZOLO[1,5A]PYRIMIDIN-7-YL AMINE DERIVATIVES IN THE TREATMENT OF NEUROLOGICAL DISORDERS | NOVARTIS AG (CH) | 2007-09-13 | — | — | WO | disclosed |