Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 8/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | BMX | P51813 | 3/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 3/20 | 0.42 |
| ▸ | KIT | P10721 | 3/20 | 0.42 |
| ▸ | SRC | P12931 | 3/20 | 0.41 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.41 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789176 | 0.99 | LCK (0.50) | LCKKDRMAPK14RXFP1RAF1 | |
| SCHEMBL4789243 | 0.94 | LCK (0.49) | LCKKDRMAPK14RAF1BMX | |
| SCHEMBL4789238 | 0.93 | LCK (0.58) | LCKKDRMAPK14RXFP1TRPV4 | |
| SCHEMBL4789582 | 0.92 | LCK (0.57) | LCKKDRMAPK14RAF1BMX | |
| SCHEMBL4789178 | 0.91 | LCK (0.58) | LCKKDRMAPK14RAF1BMX | |
| SCHEMBL4787603 | 0.88 | RAF1 (0.47) | LCKKDRMAPK14RXFP1RAF1 | |
| SCHEMBL4788649 | 0.87 | BMX (0.47) | LCKKDRMAPK14RXFP1RAF1 | |
| SCHEMBL4790218 | 0.87 | BMX (0.49) | LCKKDRMAPK14RXFP1RAF1 | |
| SCHEMBL4789266 | 0.86 | SYK (0.48) | LCKKDRMAPK14RAF1BMX | |
| SCHEMBL4789218 | 0.86 | SYK (0.49) | LCKKDRMAPK14RXFP1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |