Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.45 |
| ▸ | ATR | Q13535 | 2/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | PRKDC | P78527 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13983587 | 0.91 | PIK3CD (0.49) | PIK3CDCYP3A4PIK3CAPIK3CBATR | |
| SCHEMBL994223 | 0.87 | PIK3CD (0.66) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL13983586 | 0.84 | PIK3CD (0.51) | PIK3CDCYP3A4PIK3CAPIK3CBATR | |
| SCHEMBL994376 | 0.83 | PIK3CD (0.63) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL993155 | 0.81 | PIK3CD (0.69) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL13983683 | 0.79 | PIK3CD (0.49) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL995967 | 0.78 | PIK3CD (0.66) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL13983613 | 0.77 | PIK3CD (0.47) | PIK3CDCYP3A4PIK3CAPIK3CBATR | |
| SCHEMBL13983685 | 0.77 | PIK3CD (0.47) | PIK3CDCYP3A4PIK3CAPIK3CBATR | |
| SCHEMBL2464953 | 0.75 | PIK3CD (0.73) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008152394-A1 | PHARMACEUTICAL COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-12-18 | — | — | WO | claimed |
| WO-2008152394-A1 | PHARMACEUTICAL COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-12-18 | — | — | WO | disclosed |