Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 14/20 | 0.46 |
| ▸ | OXTR | P30559 | 8/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | CHI3L1 | P36222 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.35 |
| ▸ | CHI3L2 | Q15782 | 1/20 | 0.35 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.35 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | USP14 | P54578 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4713503 | 0.91 | AVPR1A (0.45) | AVPR1AOXTRTRPA1TRPM8CHI3L1 | |
| SCHEMBL4710762 | 0.84 | AVPR1A (0.43) | AVPR1AOXTRTRPA1TRPM8CHI3L1 | |
| SCHEMBL4760978 | 0.74 | AVPR1A (0.47) | AVPR1AOXTRTRPA1TRPM8 | |
| SCHEMBL4714355 | 0.74 | AVPR1A (0.47) | AVPR1AOXTRTRPA1TRPM8KCNH2 | |
| SCHEMBL4712455 | 0.74 | AVPR1A (0.44) | AVPR1AOXTRTRPA1TRPM8KCNH2 | |
| SCHEMBL5436364 | 0.73 | AVPR1A (0.53) | AVPR1AOXTRTRPA1TRPM8 | |
| SCHEMBL5426182 | 0.73 | AVPR1A (0.54) | AVPR1AOXTRTRPA1TRPM8BRD4 | |
| SCHEMBL5428048 | 0.73 | AVPR1A (0.52) | AVPR1AOXTRTRPA1TRPM8DRD3 | |
| SCHEMBL4713593 | 0.72 | AVPR1A (0.45) | AVPR1AOXTRKCNH2DRD4DRD3 | |
| SCHEMBL5155966 | 0.72 | AVPR1A (0.48) | AVPR1AOXTRTRPA1TRPM8BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877399-A1 | TRIAZOLE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | Pfizer Limited (GB) | 2008-01-16 | — | — | EP | claimed |
| WO-2006114706-A1 | TRIAZOLE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | PFIZER LIMITED (GB) | 2006-11-02 | — | — | WO | claimed |