Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | SCN4A | P35499 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4519215 | 0.90 | ACACB (0.47) | ACACBNPC1RAB9AHTTMEN1 | |
| SCHEMBL4519186 | 0.90 | NPC1 (0.52) | ACACBNPC1RAB9ALTA4HKCNH2 | |
| SCHEMBL4516183 | 0.89 | ACACB (0.46) | ACACBNPC1RAB9AHTTMEN1 | |
| SCHEMBL4520509 | 0.87 | NPC1 (0.44) | ACACBNPC1RAB9ALTA4HKCNH2 | |
| SCHEMBL4514304 | 0.87 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL4511372 | 0.86 | NPC1 (0.44) | NPC1RAB9ALTA4HKCNH2SMN1; SMN2 | |
| SCHEMBL4525186 | 0.86 | NPC1 (0.50) | ACACBNPC1RAB9ALTA4HKCNH2 | |
| SCHEMBL4521582 | 0.85 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL2622434 | 0.84 | ACACB (0.43) | ACACBNPC1RAB9AEPHX2 | |
| SCHEMBL4508992 | 0.84 | NPC1 (0.41) | NPC1RAB9ALTA4HKCNH2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996567-A2 | NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME | ABBOTT LABORATORIES (US) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007095601-A2 | NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME | ABBOTT LABORATORIES (US) | 2007-08-23 | — | — | WO | disclosed |