Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.56 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL58849 | 0.86 | PRMT5 (0.60) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL1949110 | 0.86 | PRMT5 (0.60) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL3153471 | 0.86 | PRMT5 (0.60) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL5106601 | 0.84 | PRMT5 (0.57) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL5106600 | 0.84 | PRMT5 (0.57) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL13969656 | 0.77 | PRMT5 (0.64) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL6114507 | 0.77 | PRMT5 (0.68) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL8264853 | 0.75 | PRMT5 (0.61) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL5185235 | 0.74 | PRMT5 (0.57) | PRMT5WDR77KMT2AGAAHTT | |
| SCHEMBL25725225 | 0.74 | PRMT5 (0.60) | PRMT5WDR77KMT2AGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945613-A1 | NOVEL 1 -BENZYL-4-PIPERIDINAMINES THAT ARE USEFUL IN THE TREATMENT OF COPD AND ASTHMA | AstraZeneca AB (SE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007053082-A1 | NOVEL 1 -BENZYL-4-PIPERIDINAMINES THAT ARE USEFUL IN THE TREATMENT OF COPD AND ASTHMA | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | disclosed |