Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.39 |
| ▸ | HTR2C | P28335 | 7/20 | 0.39 |
| ▸ | HTR2B | P41595 | 7/20 | 0.39 |
| ▸ | PNMT | P11086 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4792019 | 1.00 | HTR2A (0.39) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL3965632 | 0.70 | HTR2C (0.42) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL14091682 | 0.70 | HTR2C (0.42) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL3965627 | 0.70 | HTR2C (0.42) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL3966291 | 0.69 | HTR2C (0.43) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL3966285 | 0.69 | HTR2C (0.43) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL4792018 | 0.69 | HTR2C (0.40) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL4960457 | 0.66 | HTR2A (0.39) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL14091675 | 0.66 | HTR2A (0.50) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL13768681 | 0.64 | NAMPT (0.38) | HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926712-A1 | 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007028131-A1 | 6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[d]AZEPINES AS 5-HT2C RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2007-03-08 | — | — | WO | disclosed |