Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 19/20 | 0.77 |
| ▸ | HTR2C | P28335 | 19/20 | 0.77 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4766201 | 0.91 | HTR2A (0.75) | HTR2AHTR2C | |
| SCHEMBL4660682 | 0.89 | HTR2A (0.76) | HTR2AHTR2C | |
| SCHEMBL4661776 | 0.89 | HTR2A (0.77) | HTR2AHTR2C | |
| SCHEMBL4660486 | 0.88 | HTR2A (0.76) | HTR2AHTR2C | |
| Nelotanserin SCHEMBL2345325 | 0.87 | HTR2A (1.00) | HTR2AHTR2C | |
| Nelotanserin SCHEMBL29456962 | 0.87 | HTR2A (1.00) | HTR2AHTR2C | |
| Nelotanserin SCHEMBL29573017 | 0.87 | HTR2A (1.00) | HTR2AHTR2C | |
| SCHEMBL4659293 | 0.87 | HTR2A (0.66) | HTR2AHTR2C | |
| SCHEMBL29573349 | 0.83 | HTR2A (0.78) | HTR2AHTR2CGAA | |
| SCHEMBL5052914 | 0.83 | HTR2A (0.78) | HTR2AHTR2CGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004627-A2 | 3-PYRIDINYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007120600-A2 | 3-PYRIDINYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | disclosed |