Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 20/20 | 0.87 |
| ▸ | KIT | P10721 | 4/20 | 0.64 |
| ▸ | SRC | P12931 | 4/20 | 0.64 |
| ▸ | FLT3 | P36888 | 4/20 | 0.64 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.64 |
| ▸ | INSR | P06213 | 1/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13294294 | 0.93 | CSF1R (1.00) | CSF1RKITSRCFLT3NTRK1 | |
| SCHEMBL3291336 | 0.92 | CSF1R (0.84) | CSF1RKITSRCFLT3NTRK1 | |
| SCHEMBL3297114 | 0.90 | CSF1R (0.81) | CSF1RKITSRCFLT3NTRK1 | |
| SCHEMBL3290550 | 0.88 | CSF1R (0.91) | CSF1RKITSRCFLT3NTRK1 | |
| SCHEMBL4775328 | 0.87 | CSF1R (0.68) | CSF1RKITSRCFLT3NTRK1 | |
| SCHEMBL4572908 | 0.86 | CSF1R (0.80) | CSF1RKITSRCFLT3NTRK1 | |
| SCHEMBL3290718 | 0.86 | CSF1R (0.75) | CSF1RKITSRCFLT3NTRK1 | |
| SCHEMBL3293845 | 0.86 | CSF1R (0.76) | CSF1RKITSRCFLT3NTRK1 | |
| SCHEMBL13294302 | 0.85 | CSF1R (0.91) | CSF1RKITSRCFLT3NTRK1 | |
| SCHEMBL4572828 | 0.85 | CSF1R (0.88) | CSF1RKITSRCFLT3NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945637-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007033137-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | WO | disclosed |