Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 14/20 | 1.00 |
| ▸ | PKN1 | Q16512 | 3/20 | 0.65 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.65 |
| ▸ | CDK9 | P50750 | 2/20 | 0.58 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.58 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.58 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.58 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.58 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.58 |
| ▸ | CDK1 | P06493 | 1/20 | 0.58 |
| ▸ | PRKACA | P17612 | 1/20 | 0.58 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | AKT1 | P31749 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4771895 | 1.00 | CDC7 (1.00) | CDC7PKN1PKN2CDK9MAPKAPK2 | |
| Hydrochloric Acid SCHEMBL4773043 | 0.99 | CDC7 (0.97) | CDC7PKN1PKN2CDK9MAPKAPK2 | |
| SCHEMBL30180047 | 0.83 | CDC7 (0.71) | CDC7PKN1PKN2MAPKAPK2ROCK2 | |
| SCHEMBL24846886 | 0.83 | CDC7 (0.71) | CDC7PKN1PKN2MAPKAPK2ROCK2 | |
| SCHEMBL26092989 | 0.83 | CDC7 (0.71) | CDC7PKN1PKN2MAPKAPK2ROCK2 | |
| SCHEMBL4774821 | 0.83 | CDC7 (1.00) | CDC7PKN1PKN2CDK9MAPKAPK2 | |
| SCHEMBL4774818 | 0.83 | CDC7 (1.00) | CDC7PKN1PKN2CDK9MAPKAPK2 | |
| Hydrochloric Acid SCHEMBL4768725 | 0.82 | CDC7 (0.97) | CDC7PKN1PKN2CDK9MAPKAPK2 | |
| Hydrochloric Acid SCHEMBL4776373 | 0.82 | CDC7 (0.97) | CDC7PKN1PKN2CDK9MAPKAPK2 | |
| Hydrochloric Acid SCHEMBL4768739 | 0.82 | CDC7 (0.97) | CDC7PKN1PKN2CDK9MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660085-B1 | PYRIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-10-15 | — | — | EP | disclosed |