Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | GFER | P55789 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.56 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.56 |
| ▸ | CHKA | P35790 | 2/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL188535 | 0.86 | MCHR1 (0.48) | MAPTKDM4EGAAALDH1A1GFER | |
| SCHEMBL188110 | 0.86 | MCHR1 (0.48) | MAPTKDM4EGAAALDH1A1GFER | |
| SCHEMBL188111 | 0.86 | MCHR1 (0.48) | MAPTKDM4EGAAALDH1A1GFER | |
| Hydrochloric Acid SCHEMBL5388918 | 0.85 | MCHR1 (0.47) | MAPTKDM4EGAAALDH1A1GFER | |
| SCHEMBL3440096 | 0.83 | MAPT (0.49) | MAPTKDM4EGAAALDH1A1GFER | |
| SCHEMBL6223422 | 0.82 | MAPT (0.51) | MAPTKDM4EGAAALDH1A1GFER | |
| SCHEMBL217159 | 0.82 | MAPT (0.85) | MAPTKDM4EGAAALDH1A1GFER | |
| SCHEMBL3440110 | 0.81 | MAPT (0.53) | MAPTKDM4EGAAALDH1A1GFER | |
| Hydrochloric Acid SCHEMBL5203720 | 0.80 | MAPT (0.81) | MAPTKDM4EGAAALDH1A1GFER | |
| SCHEMBL1409679 | 0.80 | MAPT (0.53) | MAPTKDM4EGAAALDH1A1GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1986646-A1 | NOVEL AZACYCLY-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | Sanofi-Aventis (FR) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007093363-A1 | NOVEL AZACYCLY-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | SANOFI-AVENTIS (DE) | 2007-08-23 | — | — | WO | disclosed |