Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2A | P48426 | 3/20 | 0.57 |
| ▸ | PIP4K2B | P78356 | 3/20 | 0.57 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 2/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4795621 | 0.84 | PIP4K2A (0.62) | PIP4K2APIP4K2BPIP4K2CKDM4EHPGDS | |
| SCHEMBL4793924 | 0.80 | TSHR (0.42) | PIP4K2APIP4K2BPIP4K2CMEN1KMT2A | |
| SCHEMBL4795341 | 0.80 | PIP4K2A (0.58) | PIP4K2APIP4K2BPIP4K2CHPGDSIKBKB | |
| SCHEMBL3928614 | 0.79 | PIP4K2A (0.72) | PIP4K2APIP4K2BPIP4K2CHPGDSIKBKB | |
| SCHEMBL4798306 | 0.78 | PIP4K2A (0.63) | PIP4K2APIP4K2BPIP4K2CHPGDSIKBKB | |
| SCHEMBL4793932 | 0.77 | PIP4K2A (0.60) | PIP4K2APIP4K2BPIP4K2CHPGDSIKBKB | |
| SCHEMBL4793193 | 0.76 | PIP4K2A (0.59) | PIP4K2APIP4K2BPIP4K2CKDM4EHPGDS | |
| SCHEMBL4795811 | 0.75 | PIP4K2A (0.60) | PIP4K2APIP4K2BPIP4K2CHPGDSPGR | |
| SCHEMBL4796970 | 0.73 | PIP4K2A (0.63) | PIP4K2APIP4K2BPIP4K2CHPGDSIKBKB | |
| SCHEMBL4794532 | 0.73 | PIK3CD (0.44) | PIP4K2APIP4K2BPIP4K2CKDM4EHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080280891-A1 | Anti-cancer agents and uses thereof | LOCUS PHARMACEUTICALS, INC. (US) | 2008-11-13 | — | — | US | claimed |
| US-20080280891-A1 | Anti-cancer agents and uses thereof | LOCUS PHARMACEUTICALS, INC. (US) | 2008-11-13 | — | — | US | disclosed |
| WO-2008008059-A1 | ANTI-CANCER AGENTS ANS USES THEREOF | LOCUS PHARMACEUTICALS, INC. (US) | 2008-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280891-A1 | Anti-cancer agents and uses thereof | NR2E3, RB1, CBR3 | PIP4K2A 4321/4885PIP4K2B 4353/4885PIP4K2C 4501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.