Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | NPC1 | O15118 | 7/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5472147 | 0.84 | KDM4E (0.55) | KDM4EPOLBMAPTNPC1SMN1; SMN2 | |
| SCHEMBL4794018 | 0.75 | KDM4E (0.55) | KDM4EPOLBMAPTNPC1SMN1; SMN2 | |
| SCHEMBL4101185 | 0.72 | KDM4E (0.68) | KDM4EPOLBMAPTNPC1SMN1; SMN2 | |
| SCHEMBL1176020 | 0.72 | KDM4E (0.60) | KDM4EPOLBMAPTSMN1; SMN2KMT2A | |
| SCHEMBL5922444 | 0.71 | KDM4E (0.66) | KDM4EPOLBMAPTNPC1SMN1; SMN2 | |
| SCHEMBL960087 | 0.71 | KDM4E (0.66) | KDM4EPOLBMAPTNPC1SMN1; SMN2 | |
| SCHEMBL1636035 | 0.71 | KDM4E (0.66) | KDM4EPOLBMAPTNPC1SMN1; SMN2 | |
| SCHEMBL31507475 | 0.70 | KDM4E (0.64) | KDM4EPOLBMAPTNPC1SMN1; SMN2 | |
| SCHEMBL493081 | 0.70 | KDM4E (0.64) | KDM4EPOLBMAPTNPC1SMN1; SMN2 | |
| SCHEMBL29709972 | 0.68 | KDM4E (1.00) | KDM4EPOLBMAPTNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1991530-A1 | CINNOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | Amgen Inc. (US) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007098169-A1 | CINNOLINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. (US) | 2007-08-30 | — | — | WO | disclosed |