Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 5/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | MARK3 | P27448 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14292023 | 0.91 | CDK4 (0.43) | KDRAURKAAURKBCDK2MAPT | |
| SCHEMBL14293019 | 0.89 | KDR (0.44) | KDRAURKAAURKBCDK2CHEK1 | |
| SCHEMBL14292465 | 0.89 | KDR (0.44) | KDRCDK2PIM1RPS6KA3MET | |
| SCHEMBL14292655 | 0.88 | KDR (0.44) | KDRAURKAAURKBCDK2CHEK1 | |
| SCHEMBL14292646 | 0.88 | KDR (0.47) | KDRAURKACDK2IKBKBMET | |
| SCHEMBL14292464 | 0.87 | EGFR (0.47) | KDRCDK2NPC1MAPTMAPK1 | |
| SCHEMBL14292644 | 0.86 | AURKA (0.50) | KDRAURKAMET | |
| SCHEMBL14292759 | 0.84 | AURKA (0.59) | CYP2D6AURKAAURKBCDK2CHEK1 | |
| SCHEMBL14293034 | 0.84 | AURKA (0.45) | KDRAURKAAURKBCDK2CDK1 | |
| SCHEMBL14293061 | 0.83 | AURKA (0.56) | KDRAURKAAURKBCDK2IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008024634-A1 | PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-28 | — | — | WO | disclosed |
| WO-2008024634-A1 | PYRIMDINE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-28 | — | — | WO | disclosed |