Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 6/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4795390 | 0.82 | ROCK1 (0.45) | ROCK1ROCK2KMT2ACSNK1DALDH1A1 | |
| SCHEMBL353118 | 0.81 | ROCK1 (0.47) | ROCK1ROCK2KMT2AMEN1CSNK1D | |
| SCHEMBL4781265 | 0.79 | POLB (0.48) | ROCK1ROCK2KMT2AMEN1CSNK1D | |
| SCHEMBL3511697 | 0.76 | ROCK1 (0.47) | ROCK1ROCK2KMT2ACSNK1DALDH1A1 | |
| SCHEMBL351753 | 0.74 | ROCK1 (0.45) | ROCK1ROCK2KMT2ACSNK1DALDH1A1 | |
| SCHEMBL353962 | 0.73 | ROCK1 (0.46) | ROCK1ROCK2CSNK1DGSK3AGSK3B | |
| SCHEMBL4776812 | 0.72 | TSHR (0.48) | ROCK1ROCK2KMT2AMEN1MAPK14 | |
| SCHEMBL352736 | 0.72 | ROCK1 (0.40) | ROCK1ROCK2KMT2AMEN1CSNK1D | |
| SCHEMBL4725167 | 0.71 | ROCK1 (0.52) | ROCK1ROCK2CSNK1DGSK3AGSK3B | |
| SCHEMBL3511578 | 0.71 | ROCK1 (0.52) | ROCK1ROCK2CSNK1DGSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008011191-A1 | ANTIBACTERIAL HETEROCYCLIC UREAS | REPLIDYNE, INC. (US) | 2008-01-24 | — | — | WO | disclosed |