Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.32 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4796389 | 1.00 | KDM4E (0.33) | KDM4ERAB9AALDH1A1HSD17B10NR1I2 | |
| SCHEMBL14290668 | 0.94 | CYP2E1 (0.34) | KDM4ERAB9AALDH1A1HSD17B10NR1I2 | |
| SCHEMBL2432624 | 0.91 | NR1I2 (0.32) | KDM4EALDH1A1NR1I2CYP2E1HTT | |
| SCHEMBL2432640 | 0.91 | NR1I2 (0.32) | KDM4EALDH1A1NR1I2CYP2E1HTT | |
| SCHEMBL938959 | 0.88 | KDM4E (0.30) | KDM4ERAB9AALDH1A1HSD17B10 | |
| SCHEMBL12909947 | 0.88 | KDM4E (0.30) | KDM4ERAB9AALDH1A1HSD17B10 | |
| SCHEMBL2432488 | 0.87 | NR1I2 (0.36) | KDM4ERAB9AALDH1A1HSD17B10NR1I2 | |
| SCHEMBL2432492 | 0.87 | NR1I2 (0.36) | KDM4ERAB9AALDH1A1HSD17B10NR1I2 | |
| SCHEMBL102056 | 0.85 | NR1I2 (0.33) | KDM4ERAB9AALDH1A1NR1I2HTT | |
| SCHEMBL139451 | 0.85 | NR1I2 (0.33) | KDM4ERAB9AALDH1A1NR1I2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008017688-A1 | 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI-VIRAL AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-14 | — | — | WO | disclosed |
| WO-2008017688-A1 | 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI-VIRAL AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-14 | — | — | WO | disclosed |