Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.58 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CDK7 | P50613 | 2/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | CCNH | P51946 | 2/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | TXK | P42681 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 5/20 | 0.40 |
| ▸ | CA2 | P00918 | 5/20 | 0.40 |
| ▸ | CA9 | Q16790 | 5/20 | 0.40 |
| ▸ | CA12 | O43570 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4267261 | 0.84 | KDR (0.64) | KDRCCNT1CDK1CCNB1CDK2 | |
| SCHEMBL13896206 | 0.74 | CCNT1 (0.58) | KDRCCNT1CDK1CCNB1CDK2 | |
| SCHEMBL31647068 | 0.73 | KDR (0.57) | KDRCDK5MAPK1ROCK1 | |
| SCHEMBL5220947 | 0.73 | KDR (0.57) | KDRCDK5MAPK1ROCK1 | |
| SCHEMBL13896209 | 0.72 | MKNK1 (0.67) | KDRCDK2MKNK1CDC7SYK | |
| SCHEMBL4266513 | 0.70 | PLK4 (0.57) | KDRCCNT1CDK1CCNB1CDK2 | |
| SCHEMBL13896208 | 0.70 | PLK4 (0.57) | KDRCCNT1CDK1CCNB1CDK2 | |
| SCHEMBL6081930 | 0.70 | KDR (0.59) | KDRCCNT1CDK1CCNB1CDK2 | |
| SCHEMBL10242647 | 0.70 | SYK (0.67) | KDRCCNT1CDK1CCNB1CDK2 | |
| SCHEMBL3283879 | 0.69 | KDR (0.50) | KDRCCNT1CDK1CCNB1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008039359-A2 | BICYCLIC PYRIMIDINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-04-03 | — | — | WO | claimed |