Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 7/20 | 0.43 |
| ▸ | FAAH | O00519 | 6/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6388516 | 0.89 | HSD17B3 (0.46) | HSD17B3SCN9ABCL2L1 | |
| SCHEMBL6388510 | 0.89 | HSD17B3 (0.46) | HSD17B3SCN9ABCL2L1 | |
| SCHEMBL4797023 | 0.88 | HSD17B3 (0.43) | HSD17B3SCN9ABCL2L1 | |
| SCHEMBL4797028 | 0.88 | HSD17B3 (0.43) | HSD17B3SCN9ABCL2L1 | |
| SCHEMBL4799309 | 0.86 | HSD17B3 (0.45) | HSD17B3 | |
| SCHEMBL4799318 | 0.86 | HSD17B3 (0.45) | HSD17B3 | |
| SCHEMBL4798174 | 0.83 | HSD17B3 (0.46) | HSD17B3SCN9A | |
| SCHEMBL4798186 | 0.83 | HSD17B3 (0.46) | HSD17B3SCN9A | |
| SCHEMBL4804464 | 0.81 | HSD17B3 (0.39) | HSD17B3P2RX4 | |
| SCHEMBL4804473 | 0.81 | HSD17B3 (0.39) | HSD17B3P2RX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7417040-B2 | Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-08-26 | — | — | US | disclosed |