Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.47 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.44 |
| ▸ | PPARG | P37231 | 7/20 | 0.44 |
| ▸ | PPARD | Q03181 | 7/20 | 0.44 |
| ▸ | PPARA | Q07869 | 7/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TLR2 | O60603 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL12980651 | 0.97 | FFAR3 (0.55) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL26900519 | 0.92 | FFAR3 (0.50) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL2949542 | 0.92 | FFAR3 (0.50) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL25576277 | 0.92 | FFAR3 (0.50) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL2948540 | 0.92 | FFAR3 (0.50) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL2951087 | 0.92 | FFAR3 (0.50) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL16420210 | 0.92 | FFAR3 (0.50) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL15158837 | 0.92 | FFAR3 (0.50) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL22445018 | 0.92 | FFAR3 (0.50) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL18738574 | 0.92 | FFAR3 (0.50) | FFAR3HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230181748-A1 | MEANS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL AGGREGATION | VIB VZW (BE) | 2023-06-15 | — | — | US | disclosed |
| EP-4149505-A1 | MEANS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL AGGREGATION | VIB VZW (BE) | 2023-03-22 | — | — | EP | disclosed |
| US-20220033448-A1 | METHODS FOR AGGREGATION OF PROTEINS | VIB VZW (BE) | 2022-02-03 | — | — | US | disclosed |
| WO-2021229102-A1 | MEANS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL AGGREGATION | VIB VZW (BE) | 2021-11-18 | — | — | WO | disclosed |
| EP-3384939-A1 | MOLECULES AND METHODS FOR INHIBITION AND DETECTION OF PROTEINS | VIB VZW (BE) | 2018-10-10 | — | — | EP | disclosed |
| EP-2683419-B1 | MOLECULES AND METHODS FOR INHIBITION AND DETECTION OF PROTEINS | VIB VZW (BE) | 2018-05-09 | — | — | EP | disclosed |
| CN-103547296-B | For suppressing and detect molecule and the method for protein | 非营利性组织佛兰芒综合大学生物技术研究所 | 2016-08-17 | — | — | CN | disclosed |
| WO-2015132248-A2 | SEQUAMERS - A NOVEL NON-NATURAL TYPE OF PEPTIDE LIBRARIES RANDOMLY CONSTRAINED BY THEIR PRIMARY SEQUENCES | VRIJE UNIVERSITEIT BRUSSEL (VUB) (BE) | 2015-09-11 | — | — | WO | disclosed |
| CN-103547296-A | Molecules and methods for inhibition and detection of proteins | VIB VZW | 2014-01-29 | — | — | CN | disclosed |
| US-7452654-B2 | Toner production method and toner production apparatus | KONICA MINOLTA BUSINESS TECHNOLOGIES, INC. (JP) | 2008-11-18 | — | — | US | disclosed |
| US-20060160012-A1 | Toner production method and toner production apparatus | KONICA MINOLTA BUSINESS TECHNOLOGIES, INC. | 2006-07-20 | — | — | US | disclosed |