Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 4/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 2/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.30 |
| ▸ | CDK7 | P50613 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2794637 | 0.85 | ALOX5AP (0.54) | ALOX5APMKNK1MKNK2CTPS1TSHR | |
| SCHEMBL480173 | 0.84 | ALOX5AP (0.55) | ALOX5APMKNK1MKNK2CTPS1KIT | |
| SCHEMBL480283 | 0.82 | ALOX5AP (0.55) | ALOX5APMKNK1MKNK2CTPS1TSHR | |
| SCHEMBL2796309 | 0.79 | ALOX5AP (0.57) | ALOX5APMKNK1MKNK2CTPS1TSHR | |
| SCHEMBL480146 | 0.79 | ALOX5AP (0.66) | ALOX5APMKNK1MKNK2CTPS1CA2 | |
| SCHEMBL480247 | 0.79 | ALOX5AP (0.66) | ALOX5APMKNK1MKNK2CTPS1CA2 | |
| SCHEMBL480217 | 0.78 | ALOX5AP (0.60) | ALOX5APMKNK1MKNK2TSHRCA2 | |
| SCHEMBL480248 | 0.77 | ALOX5AP (0.57) | ALOX5APMKNK1MKNK2TSHR | |
| SCHEMBL480250 | 0.77 | ALOX5AP (0.58) | ALOX5APMKNK1MKNK2CA2CA9 | |
| Hydrochloric Acid SCHEMBL480177 | 0.76 | ALOX5AP (0.57) | ALOX5APMKNK1MKNK2CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064204-B1 | INHIBITORS OF 5 -LIPOXYGENASE ACTIVATING PROTEIN ( FLAP) | MERCK SHARP & DOHME (US) | 2012-02-01 | — | — | EP | claimed |
| EP-2064204-A1 | INHIBITORS OF 5 -LIPOXYGENASE ACTIVATING PROTEIN ( FLAP) | Merck & Co., Inc. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008030369-A1 | INHIBITORS OF 5 -LIPOXYGENASE ACTIVATING PROTEIN ( FLAP) | MERCK & CO., INC. (US) | 2008-03-13 | — | — | WO | disclosed |