Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 8/20 | 0.79 |
| ▸ | SYK | P43405 | 7/20 | 0.78 |
| ▸ | AURKA | O14965 | 5/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2216067 | 0.94 | BTK (0.76) | BTKSYKAURKA | |
| SCHEMBL4814294 | 0.93 | BTK (0.78) | BTKSYKAURKA | |
| SCHEMBL2216603 | 0.92 | BTK (0.72) | BTKSYKAURKA | |
| SCHEMBL4808681 | 0.91 | BTK (0.78) | BTKSYKAURKA | |
| SCHEMBL4810656 | 0.91 | BTK (0.71) | BTKSYKAURKA | |
| SCHEMBL4807292 | 0.91 | BTK (0.77) | BTKSYKAURKA | |
| SCHEMBL2217099 | 0.91 | BTK (0.77) | BTKSYKAURKA | |
| SCHEMBL12514841 | 0.89 | BTK (0.74) | BTKSYKAURKA | |
| SCHEMBL2217640 | 0.89 | BTK (1.00) | BTKSYKAURKA | |
| SCHEMBL29523904 | 0.89 | BTK (1.00) | BTKSYKAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7405295-B2 | Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds | CGI PHARMACEUTICALS, INC. (US) | 2008-07-29 | — | — | US | disclosed |