Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 5/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL480279 | 0.89 | ALOX5AP (0.49) | ALOX5APCA2CA9S1PR1ACHE | |
| SCHEMBL480391 | 0.85 | ALOX5AP (0.53) | ALOX5APACHENPC1MAPTRAB9A | |
| SCHEMBL480157 | 0.82 | ALOX5AP (0.53) | ALOX5APNPC1MAPTRAB9A | |
| SCHEMBL480225 | 0.82 | ALOX5AP (0.53) | ALOX5APNPC1MAPTRAB9A | |
| SCHEMBL480274 | 0.81 | ALOX5AP (0.51) | ALOX5APNPC1MAPTRAB9A | |
| SCHEMBL480260 | 0.79 | ALOX5AP (0.53) | ALOX5APNPC1MAPTRAB9A | |
| SCHEMBL480250 | 0.79 | ALOX5AP (0.58) | ALOX5APCA2CA9S1PR1NPC1 | |
| SCHEMBL480146 | 0.79 | ALOX5AP (0.66) | ALOX5APCA2CA9NPC1MAPT | |
| SCHEMBL480247 | 0.79 | ALOX5AP (0.66) | ALOX5APCA2CA9NPC1MAPT | |
| SCHEMBL480195 | 0.78 | ALOX5AP (0.52) | ALOX5APNPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064204-B1 | INHIBITORS OF 5 -LIPOXYGENASE ACTIVATING PROTEIN ( FLAP) | MERCK SHARP & DOHME (US) | 2012-02-01 | — | — | EP | claimed |